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| β-catenin is up-expressed and predicts poor overall survival of breast cancer |
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| DOI：10.46701/APJBG.2018022018007 |
| KeyWord:β-catenin, breast cancer, prognosis, biomarker |
| Author | Institution |
| Lizhou Jia |
Key Laboratory of Antibody Technique of National Health and Family Planning Commission, Nanjing, Jiangsu 211166, China; Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 211166, China |
| Xiaobing Yang |
Department of Pathology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210000, China |
| Wei Zhao |
Department of Pathology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210000, China |
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| Abstract: |
| Breast cancer (BC) is one of the most common malignant tumors in women.The majority of BC cells contain at least one or more up-expressed oncogene. β-catenin is found overexpressed in various epithelial cell cancers and has the function of inducing cancer cell proliferation, invasion and metastasis. However, the expression of β-catenin and its prognostic value in BC is not yet clear. In this study, mRNA and β-catenin proteins expressed in BC tissues have been explored. Quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) on tissue microarrays (TMA) were performed to examine the level of β-catenin mRNA and protein in BC tissues. The association between β-catenin and clinical characteristics and prognostic value were also explored. β-catenin mRNA and protein were found over-expressed in BC tissues when compared with matched tumor neighbor tissues. A high degree of β-catenin staining in BC tissues was significantly associated with tumor size, Ki67 expression, lymph node status and TNM stage. β-catenin up-expression was also able to predict poor overall survival (OS) rates. These results indicated that β-catenin may be a useful prognostic molecular biomarker for BC patients. |
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