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| Prognostic and predictive value of IGFBP-6 in head and neck squamous cell carcinoma |
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| DOI：10.46701/APJBG.2018022018109 |
| KeyWord:head and neck cancer, insulin-like growth factor binding protein-6, immunohistochemistry, prognosis |
| Author | Institution |
| Yue Qi |
Department of Oncology and Clinical Bio-bank, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China |
| Mingming Tang |
Department of Head and Neck Surgery, Affiliated Tumor Hospital of Nantong University, Nantong Tumor Hospital, Nantong, Jiangsu 226361, China |
| Wencheng Dai |
Department of Head and Neck Surgery, Affiliated Tumor Hospital of Nantong University, Nantong Tumor Hospital, Nantong, Jiangsu 226361, China |
| Huaiqin Zhang |
Department of Otolaryngology and Head and Neck Surgery, Rugao People's Hospital, Nantong, Jiangsu 226500, China |
| Liang Han |
Department of Otolaryngology and Head and Neck Surgery, Rugao People's Hospital, Nantong, Jiangsu 226500, China |
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| Abstract: |
| The aim of this study was to assess insulin-like growth factor binding protein-6 (IGFBP-6) expression, and its potential value as a prognostic indicator of survival in patients with head and neck cancer (HNC). Quantitative realtime polymerase chain reaction (qRT-PCR) and immunohistochemistry analyses were used to determine IGFBP-6 mRNA and protein expression, respectively, in HNC. The correlations between IGFBP-6 expression levels and clinical characteristics or prognoses were determined via statistical analyses. IGFBP-6 mRNA and protein levels were significantly higher in HNC tissues than in normal adjacent tissues (P<0.000 1). High IGFBP-6 expression in cancer tissues was significantly associated with sex (P=0.013), tobacco consumption (P=0.021), tumor location (P=0.001), histopathological grade (P=0.030), T stage(P=0.04), and tumor classification. IGFBP-6 expression in buccal squamous cell carcinoma (BSCC) tissues was correlated with laryngeal squamous cell carcinoma (LSCC) development (P=0.001) but not tongue squamous cell carcinoma (TSCC) development (P=0.355). High IGFBP-6 expression (P=0.001), histopathological grade (P=0.020), T stage (P=0.007), lymph node metastasis (P=0.001), and pTNM stage (P=0.001) were identified as significant prognostic factors for survival. Kaplan-Meier survival curves demonstrated that patients with high IGFBP-6 levels or stage Ⅲ + Ⅳ cancer exhibited significantly shorter survival times than patients with low IGFBP-6 levels or stage Ⅰ + Ⅱ disease. Our findings provide the first evidence that high IGFBP-6 expression is associated with poor prognosis in HNC. |
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