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| A survey of phenotype distribution of subgroup A2, blood groups MNS, P, and Kell in the Kazak nationality living in northern Xinjiang of China |
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| DOI：10.46701/APJBG.2018032018118 |
| KeyWord:RBC blood group, subgroup A2, blood groups MNS, P, Kell, gene frequency |
| Author | Institution |
| Fen Qiu |
Department of Transfusion, Kuitun Hospital of Xinjiang's Yili Kazak Autonomous Prefecture, Kuitun, Xinjiang, 833200, China |
| Gulibahati |
Department of Transfusion, Kuitun Hospital of Xinjiang's Yili Kazak Autonomous Prefecture, Kuitun, Xinjiang, 833200, China |
| Jun Wen |
Department of Transfusion, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, Xinjiang, 830000, China; |
| Xuemei Tian |
Department of Transfusion, Friendship Hospital of Xinjiang's Yili Kazak Autonomous Prefecture, Yili, Xinjiang, 835000, China. |
| Asmuguli |
Department of Transfusion, Kuitun Hospital of Xinjiang's Yili Kazak Autonomous Prefecture, Kuitun, Xinjiang, 833200, China |
| Hui Pan |
Department of Transfusion, Kuitun Hospital of Xinjiang's Yili Kazak Autonomous Prefecture, Kuitun, Xinjiang, 833200, China |
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| Abstract: |
| The research was undertaken to study the phenotypic polymorphisms of the subgroup A2, blood groups MNS, P, and Kell in the Kazakh population in northern Xinjiang, China and establish data on rare blood group antigens in the Kazakh population, in order to provide references for clinical blood transfusion safety and prevention of hemolytic disease of the new born. In this study, 6,862 unrelated Kazakh individuals in northern Xinjiang were randomly selected, and their blood samples were collected for serological testing. The antigens of A, B, A1, M, N, P1 and K were detected by serological saline tube method, and the antigens of S, s, and k were detected by the microcolumn gel antiglobulin card method. The results were as follows: ① The detection rates of subgroup A2 in group A and group AB were 7.08% and 21.79%, respectively; ② The allele frequencies of the blood groups MNS, P and Kell were M=0.5668, N=0.4332, S=0.1860, s= 0.8140, P1=0.2848, P2=0.7152, K1=0.0096, K2=0.9904. The observed values and expected values of frequency distribution of genotypes were compared by χ2 test, which conformed to the Hardy-Weinberg genetic law (P>0.05); ③ Fourteen cases of S-s- rare phenotype were detected in MNS blood group system, with a frequency of 1.16%; ④ The frequency of K antigen in the Kell blood group system was 1.92%. One case of rare KK homozygote was detected, with a frequency of 0.034%. Our study suggested that the distribution of gene frequency of subgroup A2, blood groups MNS, P and Kell in the Kazakh population in northern Xinjiang has its own characteristics, and their blood group MNS has unique genotypes. The positive rate of K antigen of blood group Kell in the Kazakh population was significantly higher than Chinese Han population. |
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