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| Macropinocytosis and SARS-CoV-2 cell entry |
| Received:April 05, 2021 Revised:April 25, 2021 |
| View Full Text View/Add Comment Download reader |
| DOI：10.46701/BG.2021012021110 |
| KeyWord:SARS-CoV-2 macropinocytosis endocytosis neuropilin-1 viral cell entry |
| Author | Institution |
| Xiaowei Sun |
State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Frontiers Science Center for Cell Responses, Nankai University, Tianjin 300071, China |
| Wenyue Zheng |
State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Frontiers Science Center for Cell Responses, Nankai University, Tianjin 300071, China |
| Rui Hua |
State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Frontiers Science Center for Cell Responses, Nankai University, Tianjin 300071, China |
| Yujie Liu |
State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Frontiers Science Center for Cell Responses, Nankai University, Tianjin 300071, China |
| Li Wang |
State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Frontiers Science Center for Cell Responses, Nankai University, Tianjin 300071, China |
| Yun-Gi Kim |
Research Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Minato-Ku, Tokyo 105-8512, Japan |
| Xinqi Liu |
State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, China |
| Hitomi Mimuro |
Department of Infection Microbiology, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan |
| Zhongyang Shen |
Organ Transplant Department, Tianjin First Central Hospital, Tianjin 300192, China;NHC Key Laboratory of Critical Care Medicine, Tianjin First Central Hospital, Tianjin 300192, China |
| Lian Li |
State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Frontiers Science Center for Cell Responses, Nankai University, Tianjin 300071, China |
| Sei Yoshida |
State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Frontiers Science Center for Cell Responses, Nankai University, Tianjin 300071, China;Organ Transplant Department, Tianjin First Central Hospital, Tianjin 300192, China;Research Institute of Transplant Medicine, Nankai University, Tianjin 300071, China |
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| Abstract: |
| Macropinocytosis is a type of large-scale endocytosis that is triggered by the interaction of receptor proteins and ligands, such as growth factors, cytokines, chemokines, and lipopolysaccharide (LPS). Macropinocytosis ingests the extracellular fluid solutes and conveys them into the lysosome in the context of cell growth and differentiation. Aside from its physiological functions, macropinocytosis has been observed in viral infections. While the infectious mechanism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still unknown, recent studies suggest the involvement of macropinocytosis in its cell entry. In this review, we discuss the roles of endocytosis in SARS-CoV/SARS-CoV-2 cell entries and propose a hypothetical role of macropinocytosis in SARS-CoV-2 cell entry. |
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