Macropinocytosis and SARS-CoV-2 cell entry
Received:April 05, 2021  Revised:April 25, 2021
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DOI:10.46701/BG.2021012021110
KeyWord:SARS-CoV-2  macropinocytosis  endocytosis  neuropilin-1  viral cell entry
                                
AuthorInstitution
Xiaowei Sun State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Frontiers Science Center for Cell Responses, Nankai University, Tianjin 300071, China
Wenyue Zheng State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Frontiers Science Center for Cell Responses, Nankai University, Tianjin 300071, China
Rui Hua State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Frontiers Science Center for Cell Responses, Nankai University, Tianjin 300071, China
Yujie Liu State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Frontiers Science Center for Cell Responses, Nankai University, Tianjin 300071, China
Li Wang State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Frontiers Science Center for Cell Responses, Nankai University, Tianjin 300071, China
Yun-Gi Kim Research Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Minato-Ku, Tokyo 105-8512, Japan
Xinqi Liu State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, China
Hitomi Mimuro Department of Infection Microbiology, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan
Zhongyang Shen Organ Transplant Department, Tianjin First Central Hospital, Tianjin 300192, China;NHC Key Laboratory of Critical Care Medicine, Tianjin First Central Hospital, Tianjin 300192, China
Lian Li State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Frontiers Science Center for Cell Responses, Nankai University, Tianjin 300071, China
Sei Yoshida State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Frontiers Science Center for Cell Responses, Nankai University, Tianjin 300071, China;Organ Transplant Department, Tianjin First Central Hospital, Tianjin 300192, China;Research Institute of Transplant Medicine, Nankai University, Tianjin 300071, China
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Abstract:
      Macropinocytosis is a type of large-scale endocytosis that is triggered by the interaction of receptor proteins and ligands, such as growth factors, cytokines, chemokines, and lipopolysaccharide (LPS). Macropinocytosis ingests the extracellular fluid solutes and conveys them into the lysosome in the context of cell growth and differentiation. Aside from its physiological functions, macropinocytosis has been observed in viral infections. While the infectious mechanism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still unknown, recent studies suggest the involvement of macropinocytosis in its cell entry. In this review, we discuss the roles of endocytosis in SARS-CoV/SARS-CoV-2 cell entries and propose a hypothetical role of macropinocytosis in SARS-CoV-2 cell entry.
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