A massive dose of allogeneic platelet gel for wound hemostatic therapy on patients with giant thoracic aortic aneurysm: report of 2 cases
Received:February 25, 2021  Revised:March 24, 2021
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DOI:10.46701/BG.2021012021105
KeyWord:allogeneic platelet  platelet-rich plasma  platelet gel  thoracic aortic aneurysms
                       
AuthorInstitution
Jianjun Wu Department of Blood Transfusion, GuiQian International General Hospital, Guiyang, Guizhou 550018, China
Bin Jiang Department of Cardiothoracic Surgery, GuiQian International General Hospital, Guiyang, Guizhou 550018, China
Renxue Xiang Department of Blood Transfusion, GuiQian International General Hospital, Guiyang, Guizhou 550018, China
Ronghui Shi Department of Blood Transfusion, GuiQian International General Hospital, Guiyang, Guizhou 550018, China
Changsheng He Department of Blood Transfusion, GuiQian International General Hospital, Guiyang, Guizhou 550018, China
Kang Yang Department of Cardiothoracic Surgery, GuiQian International General Hospital, Guiyang, Guizhou 550018, China
Xin Cui Guizhou Province Blood Center, Guiyang, Guizhou 550002, China
Shuming Zhao Department of Blood Transfusion, GuiQian International General Hospital, Guiyang, Guizhou 550018, China
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Abstract:
      Autologous platelet-rich plasma (PRP) or platelet gel (PG) has been widely used in clinical treatment. Allogeneic PRP or PG may also become a safe and effective alternative method. In this study, two cases with giant thoracic aortic aneurysm were reported where massive doses of allogeneic PG were used to spray the thoracic aortic aneurysm wall suture wrapped in artificial blood vessels, tumors blood vessel wall anastomotic site, and incision site of surgical operation. The volumes of 220 mL and 250 mL PG were applied on two patients respectively, to clot bleeding and decrease the mediastinal and pericardial drainage days after operation. The drainage tubes were pulled out on the 4th day after operation. The patients were transferred from ICU to a cardiothoracic surgery ward on the 4th and 5th day respectively. This study suggests that allogeneic platelet concentrate, as a source of PRP to prepare PG, may be used to promote and help the clotting and wound healing on surgical operation.
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